The first bowl will be a sore upon the worshippers of Antichrist. Revelation 16:2 says, "And the first went and poured out his bowl into the earth; and there came an evil and malignant sore upon the men who have the mark of the beast and worship his image." In His last fury, God will mark the rebellious ones with a sore on their skin because they bear the mark of the beast.
With the second bowl, the sea will become blood and every living soul in the sea will die. Revelation 16:3 says, "And the second poured out his bowl into the sea, and it became blood like that of a dead man; and every living soul that was in the sea died."
When the third bowl is poured out, the rivers and springs will become blood, and people will drink the blood-water (Rev. 16:4-7).
When the fourth bowl is poured out, the sun will burn men with fire, and men will be burned with great heat and blaspheme the name of God (Rev. 16:8-9).
The fifth bowl will be poured out on the kingdom of Antichrist. His kingdom will become darkened, and they will gnaw their tongues for pain and blaspheme God for their pains and for their sores (Rev. 16:10-11).
The plague of the sixth bowl is poured out upon the great river Euphrates, which is dried up so that the way of the kings from the rising of the sun might be prepared (Rev. 16:12).