The beast had ten horns (7:20a). This signifies that it had ten kings (Rev. 17:12-13).
A small horn came up among the ten horns, and three of them were uprooted before them (Dan. 7:8a, 20b, 24). This signifies that Antichrist will come up among the ten kings, and before him three of them will be destroyed. In this way Antichrist will become the strongest horn.
In this horn were eyes like the eyes of a man and a mouth speaking great things (Dan. 7:8b, 20c, 25a). This signifies that Antichrist will have sharp sight to perceive things and a mouth to speak great things against God (Rev. 13:5a, 6). Because of this, Antichrist will be slain, and his body will be destroyed and given to the burning fire (Dan. 7:11; Rev. 19:20).
This horn (Antichrist) waged war with the saints, wore out the saints of the Most High for three and a half years, and prevailed against them (Dan. 7:21, 25; Rev. 13:7a).
This horn (Antichrist) intended to change the times and the law (Dan. 7:25).
This horn (Antichrist) will be judged by God, and his dominion will be taken away, so that it will be annihilated and destroyed unto the end (vv. 11b, 26).